APA
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Antonini, M. J., Sahasrabudhe, A., Tabet, A., Schwalm, M., Rosenfeld, D., Garwood, I. C., … Anikeeva, P. (2021). Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing. Advanced Functional Materials.
Chicago/Turabian
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Antonini, Marc‐Joseph, Atharva Sahasrabudhe, A. Tabet, Miriam Schwalm, Dekel Rosenfeld, Indie C. Garwood, Jimin Park, et al. “Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing.” Advanced Functional Materials (2021).
MLA
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Antonini, Marc‐Joseph, et al. “Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing.” Advanced Functional Materials, 2021.
BibTeX Click to copy
@article{marc2021a,
title = {Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing},
year = {2021},
journal = {Advanced Functional Materials},
author = {Antonini, Marc‐Joseph and Sahasrabudhe, Atharva and Tabet, A. and Schwalm, Miriam and Rosenfeld, Dekel and Garwood, Indie C. and Park, Jimin and Loke, Gabriel and Khudiyev, T. and Kanık, Mehmet and Corbin, Nathan and Canales, Andrés and Jasanoff, A. and Fink, Y. and Anikeeva, P.}
}
Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical, and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low‐loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here, two fabrication approaches are introduced: 1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and 2) a metal convergence drawing with traditionally non‐drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low‐impedance metallic electrodes and low‐loss waveguides, capable of recording optically‐evoked and spontaneous neural activity in mice over several weeks. These fibers are coupled with a light‐weight mechanical microdrive (1 g) that enables depth‐specific interrogation of neural circuits in mice following chronic implantation. Finally, the compatibility of these fibers with magnetic resonance imaging is demonstrated and they are applied to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber‐based neural probes in neuroscience and neuroengineering.